The cell is a remarkable biological entity that serves as the basis of life as we know it. In eukaryotes, the intracellular compartments of the cell are highly organized – akin to a factory and its multiple departments and offices. Notably, not all ‘cells’ are the same; and they can vary drastically in their form, arrangement, morphology, movement, mitotic rate, and even the abundance of specific organelles depending on the tissue they reside in and their specific functions. The development of fluorescence microscopy in the 20th century opened an inexhaustible number of doors for how biologists study the fundamentals of cell biology, and provided an extremely useful tool for the visualization of what is happening inside the cell under certain conditions.
Throughout the evolution of biological research, microscopy continues to function as a fundamental tool for scientists of many different fields, and the constant advancements in microscopy sciences has allowed the progress of research in ways that were unimaginable half a century ago. I exploit the realm of fluorescence microscopy to visualize the events that occur inside the cell when infected with a virus.
How does fluorescence microscopy works? Here a quick review:
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